DESCUBREN UNA MOLÉCULA QUE ABRE UN CAMINO PARA COMBATIR EL PARKINSON

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Se trata de un derivado de un conocido antibiótico, que tiene efectos protectores sobre las neuronas que se ven afectadas por la enfermedad. Fue desarrollada entre un instituto de Tucumán y uno de París. Si bien se trata de un estudio in vitro genera buenas expectativas.

Un grupo de investigadores del Conicet de Tucumán demostró en estudios in vitro que un derivado de un conocido antibiótico, la tetraciclina demeclociclina (DMC), tiene efectos protectores sobre las neuronas que se ven afectadas en la enfermedad de Parkinson (EP), lo que sienta las bases para avanzar a estudios preclínicos para comprobar si puede evitar la muerte de estas células y, de ese modo, detener la progresión de la patología que afecta al 1% de la población mayor a 65 años.

Se trata de una molécula desarrollada entre el Instituto de Investigación en Medicina Molecular y Celular Aplicada (IMMCA, Conicet-UNT-Siprosa), con base en Tucumán, y el Instituto del Cerebro de París (Francia), cuya investigación fue publicada recientemente en la prestigiosa revista Cells.

«De acuerdo a la literatura científica y a resultados de trabajos previos que realizamos con el grupo de investigación, sabíamos que hay algunas tetraciclinas (antibióticos que se usan para varias enfermedades) que tienen capacidades neuroprotectoras, lo que serviría para un uso potencial tanto para Parkinson como para Alzheimer que son las dos enfermedades que estamos investigando», explicó a Télam Rodrigo Tomas-Grau, coautor del estudio y becario posdoctoral del Conicet en IMMCA.

«Lo que nosotros hicimos junto al Instituto del Cerebro de París (Francia) fue sintetizar una nueva molécula a partir de la demeclociclina que no tiene capacidad antibiótica»

«En ese contexto había un trabajo con demeclociclina que demostraba que esta molécula impedía que la proteína alfa-sinucleína (aS) -presente en unas células cerebrales llamadas dopaminérgicas- comience a agregarse de forma tóxica, que es lo que puede desencadenar el Parkinson, o sea que interfería en ese proceso».

Tomas-Grau explicó que «el problema es que las enfermedades como Parkinson y Alzheimer son enfermedades crónicas y progresivas, entonces no se puede medicar con antibióticos de por vida ya que conllevaría a otro problema que sería la resistencia a esos antibióticos».

«Lo que nosotros hicimos junto al Instituto del Cerebro de París (Francia) fue sintetizar una nueva molécula a partir de la demeclociclina que no tiene capacidad antibiótica, es decir que le modificamos un par de cosas de su estructura química para quitarle esa capacidad», describió.

Una vez que se obtuvo esa nueva molécula realizaron pruebas para ver si mantenía su capacidad neuroprotectora y descubrieron que no sólo continuaba esa propiedad, sino que era mejor aún que la demeclociclina original con capacidad antibiótica.

Además de interferir en la función tóxica de la proteína alfa-sinucleína (aS), las y los investigadores comprobaron en el instituto parisino que la molécula de demeclociclina que había creado tenía efectos antiinflamatorios sobre la neuronas que habían sido afectadas por la toxicidad de la proteína.

Florencia González Lizárraga, becaria posdoctoral del IMMCA y la otra coautora de este descubrimiento, señaló -por su parte- que el nuevo trabajo forma parte de un «ambicioso proyecto de investigación» financiado por la Agencia Nacional de Promoción Científica (ANPCyT), y que contó con un subsidio de la Asociación France Parkinson.

Los investigadores destacaron que los resultados sugieren que esta molécula puede ser una candidata prometedora como fármaco para el desarrollo de estudios preclínicos de la enfermedad de Parkinson en modelos animales.

Consultado sobre los siguientes pasos, Tomas-Grau señaló que «ésta es la primera fase, que es el desarrollo de la molécula y su prueba en tubos de ensayo y con células; con esta evidencia, el próximo paso sería comenzar a probar en modelos animales, esto es ratones transgénicos que poseen características de la enfermedad, lo que se llaman estudios pre-clínicos, para comprobar eficacia y seguridad».

Los resultados sugieren que esta molécula puede ser una candidata prometedora como fármaco para el desarrollo de estudios preclínicos de la enfermedad de Parkinson en modelos animales.

«Sólo después de haber sorteado exitosamente muchos de estos ensayos en organismos modelo de la enfermedad, podría ser candidata para ensayos en humanos. El camino es largo, pero dada la abundante evidencia del efecto neuroprotector de tetraciclinas, creemos que justifica seguir trabajando en esta dirección», indicó Tomas-Grau, quien también indicó que «más allá de este desarrollo seguimos en la búsqueda de nuevas moléculas; estamos haciendo el mismo camino con otras tres y estamos muy avanzados. Esta es una rueda de síntesis de nuevas moléculas que se van presentando al mundo para desarrollar estudios específicos y llegar a nuevos fármacos».

El estudio fue liderado por Rosana Chehín, doctora en Bioquímica e investigadora del Conicet en el IMMCA, y Bruno Figadère, de la Universidad de Paris-Sud Saclay, en Francia; también integran el grupo la doctora Raisman Vozari y Michael Patrick, quienes fueron clave en la articulación con Francia.

Los investigadores destacaron que los resultados sugieren que esta molcula puede ser una candidata prometedora como frmaco para el desarrollo de estudios preclnicos de la enfermedad Foto Prensa

Los investigadores destacaron que los resultados sugieren que esta molécula puede ser una candidata prometedora como fármaco para el desarrollo de estudios preclínicos de la enfermedad / Foto: Prensa

La Enfermedad de Parkinson fue descripta y caracterizada hace más de 200 años; sin embargo, al día de hoy no existe un fármaco capaz de detener o siquiera enlentecer el proceso de muerte neuronal, solamente están disponibles los de carácter paliativo que actúan aliviando los síntomas de la enfermedad.

Se trata de una afección degenerativa del cerebro asociada a síntomas motores (lentitud de movimientos, temblores, rigidez y desequilibrio) y a otras complicaciones como el deterioro cognitivo, los trastornos mentales, del sueño, el dolor y alteraciones sensoriales.

A nivel mundial, la discapacidad y las defunciones debidas a la enfermedad de Parkinson están aumentando más rápidamente que las de cualquier otro trastorno neurológico.

Según informó la Organización Mundial de la Salud, la prevalencia de la enfermedad de Parkinson se ha duplicado en los últimos 25 años y se estima que para 2030 podría volver a duplicarse.

Fuente: Telam

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  244. I’m impressed, I must say. Seldom do I come across a blog that’s equally educative and engaging, and let me tell you, you have hit the nail on the head. The issue is something not enough folks are speaking intelligently about. Now i’m very happy that I came across this during my search for something regarding this.

  246. Howdy! Do you use Twitter? I’d like to follow you if that would be okay. I’m undoubtedly enjoying your blog and look forward to new posts.

  247. I have observed that in the world today, video games include the latest fad with kids of all ages. Often times it may be not possible to drag your kids away from the games. If you want the best of both worlds, there are many educational gaming activities for kids. Great post.

  248. A different issue is that video gaming has become one of the all-time main forms of excitement for people of various age groups. Kids enjoy video games, and also adults do, too. The actual XBox 360 is one of the favorite games systems for those who love to have a lot of games available to them, plus who like to relax and play live with other individuals all over the world. Many thanks for sharing your thinking.

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  251. An outstanding share! I’ve just forwarded this onto a co-worker who had been conducting a little research on this. And he actually ordered me dinner due to the fact that I discovered it for him… lol. So allow me to reword this…. Thanks for the meal!! But yeah, thanks for spending the time to discuss this subject here on your internet site.

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  256. Interesting blog post. Some tips i would like to contribute is that laptop memory needs to be purchased if the computer can no longer cope with what you do with it. One can deploy two RAM memory boards of 1GB each, for example, but not certainly one of 1GB and one of 2GB. One should look for the maker’s documentation for own PC to be certain what type of ram is necessary.

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  259. Yet another thing I would like to talk about is that rather than trying to suit all your online degree training on times that you complete work (since most people are fatigued when they return), try to get most of your sessions on the saturdays and sundays and only 1 or 2 courses on weekdays, even if it means a little time away from your weekend break. This is fantastic because on the saturdays and sundays, you will be far more rested in addition to concentrated with school work. Many thanks for the different ideas I have discovered from your website.

  261. Thanks for discussing your ideas. I’d also like to state that video games have been ever evolving. Modern technology and innovations have assisted create authentic and fun games. These kind of entertainment games were not as sensible when the real concept was first being experimented with. Just like other forms of technological know-how, video games also have had to develop through many years. This itself is testimony to the fast growth of video games.

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  269. I have observed that good real estate agents all over the place are starting to warm up to FSBO ***********. They are seeing that it’s more than just placing a sign post in the front yard. It’s really about building relationships with these traders who sooner or later will become purchasers. So, when you give your time and efforts to supporting these vendors go it alone : the «Law connected with Reciprocity» kicks in. Great blog post.

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  277. Something else is that when looking for a good on the web electronics retail outlet, look for web shops that are continually updated, retaining up-to-date with the latest products, the most beneficial deals, as well as helpful information on services and products. This will make certain you are dealing with a shop that really stays on top of the competition and provide you what you need to make educated, well-informed electronics buying. Thanks for the crucial tips I have really learned from your blog.

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  294. Once I initially commented I clicked the -Notify me when new feedback are added- checkbox and now every time a comment is added I get 4 emails with the identical comment. Is there any way you possibly can take away me from that service? Thanks!

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  302. I should say also believe that mesothelioma cancer is a exceptional form of cancer malignancy that is generally found in people previously familiar with asbestos. Cancerous cells form within the mesothelium, which is a shielding lining that covers a lot of the body’s bodily organs. These cells typically form within the lining of the lungs, tummy, or the sac which actually encircles the heart. Thanks for revealing your ideas.

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  310. Thanks for the helpful post. It is also my opinion that mesothelioma cancer has an really long latency period of time, which means that symptoms of the disease may well not emerge till 30 to 50 years after the primary exposure to asbestos. Pleural mesothelioma, that’s the most common type and has an effect on the area round the lungs, might cause shortness of breath, upper body pains, as well as a persistent coughing, which may result in coughing up blood vessels.

  312. Hi there! This blog post couldn’t be written any better! Going through this article reminds me of my previous roommate! He always kept preaching about this. I most certainly will send this article to him. Pretty sure he’s going to have a good read. Many thanks for sharing!

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